Published on Oct 1, 2021
Internuclear ophthalmoplegia (INO)

How do you term the condition where there is the inability to perform the gaze shown in the MRI due to the lesion in the MLF?

  • Internuclear ophthalmoplegia (INO)
  • It is an ocular movement disorder that presents as inability to perform conjugate lateral gaze and ophthalmoplegia due to damage to the interneuron between two nuclei of cranial nerves (CN) VI and CN III (internuclear).
  • This interneuron is called the medial longitudinal fasciculus (MLF). The MLF can be damaged by any lesion (e.g., demyelinating, ischemic, neoplastic, inflammatory) in the pons or midbrain.